Obesity, airway hyperresponsiveness, and inflammation

Obesity Induced by Neonatal Overfeeding Worsens Airway Hyperresponsiveness and Inflammation

BACKGROUND Obesity is a risk factor for the development of certain respiratory diseases, and neonatal overfeeding results in an early onset of obesity in adulthood. However, the influence of neonatal overfeeding on respiratory diseases has rarely been studied. Therefore, this paper is aimed at investigating the effect of neonatal overfeeding on airway responsiveness and inflammation. METHODOL...

HIGHLIGHTED TOPIC Pulmonary Physiology and Pathophysiology in Obesity Obesity, airway hyperresponsiveness, and inflammation

Shore SA. Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 108: 735–743, 2010. First published October 29, 2009; doi:10.1152/japplphysiol.00749.2009.— Epidemiological data indicate that obesity is a risk factor for asthma, but the mechanistic basis for this relationship is not established. Here we review data from human subjects and animal models investigating the relations...

Tanshinone IIA attenuates ovalbumin-induced airway inflammation and hyperresponsiveness in a murine model of asthma

Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...

Airway hyperresponsiveness: relation to asthma and inflammation?

Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling.

To study the physiopathology and significance of asymptomatic airway hyperresponsiveness (AHR), the clinical and bronchial immunohistological parameters were evaluated in subjects with asymptomatic and symptomatic AHR. Asymptomatic subjects with AHR (eight females/two males, no respiratory symptoms, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one ...